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"Katy Perry Remains to be the Queen of Camp". It's authorized to be used in children aged 2--17 years who have compensated liver disease from chronic hepatitis B. In a placebo-managed trial in children who have chronic hepatitis B with out HIV infection, lamivudine was nicely tolerated, with virologic response (clearance of HBV DNA and HBeAg) in 23% of children receiving fifty two weeks of lamivudine therapy, compared with 13% in placebo recipients (679).
Response rates were higher (35%) for kids with baseline serum transaminases greater than two instances regular (679). In a 2-yr, open-label extension of this examine, 213 kids who remained HBeAg-positive after 1 year of therapy were continued on lamivudine remedy; virologic response was seen in 21% of the original lamivudine recipients, in contrast with 30% of prior placebo recipients, indicating that additional clinical response may happen over time with extended treatment (680).
However, longer duration of lamivudine therapy also was related to progressive improvement of lamivudine-resistant HBV, with base pair substitutions on the tyrosine-methionine-aspartate-aspartate (YMDD) locus of HBV DNA polymerase.
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